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OsteoBites

About OsteoBites

OsteoBites is a weekly webinar and podcast where Osteosarcoma Experts share their research, hope, and innovation. The sessions are led and paneled by OsteoWarriors. All are welcome to join the live webinar, and invited to listen to or watch the recorded sessions.

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Upcoming Episodes

March 12, 2026

Identifying mechanisms of chemoresistance in metastatic osteosarcoma using molecular barcoding
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March 26, 2026

Targeting EPHA2 with dual-armored CAR T cells for immunotherapy in pediatric osteosarcoma
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April 2, 2026

Extracellular Matrix Degradation to Overcome Osteosarcoma Chemoresistance
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April 9, 2026

Zanzalintinib in Osteosarcoma: Balancing Disease Control and Quality of Life
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April 23, 2026

Targeting Perioperative Myeloid Responses Through NOD/RIPK2 Modulation to Prevent Metastatic Progression in Osteosarcoma
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May 7, 2026

Oncogenic structural variation in the genome of pediatric osteosarcoma
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Save the Date for Future Episodes

May 14, 2026

David Shulman, MD

May 28, 2026

A Guide to FACTOR 2026 Scientific Panels with Matteo Trucco, MD

Past Episodes

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March 5, 2026

New insights into shared molecular and genomic features between humans and dogs with OS
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February 26, 2026

Implementing personalized, adaptive therapies in osteosarcoma
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February 5, 2026

High-throughput characterization of pathobiological responses in osteosarcoma tumors treated with LRRC15-targeted radiotherapy to uncover curative co-treatment approaches
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January 15, 2026

Next generation dual-CAR gamma delta T cells for the treatment of pediatric osteosarcoma
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January 8, 2026

Insights from the Musculoskeletal Tumor Society (MSTS) December 2025 Annual Meeting
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December 11, 2025

Results of a phase II trial of olaparib in combination with ceralasertib in patients with recurrent and unresectable osteosarcoma
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December 4, 2025

Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution
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November 6, 2025

Synergy of ATM and PARP Inhibitors in Pediatric Osteosarcoma
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October 23, 2025

Comparative Extracellular Vesicle (EV) Biomarkers for Osteosarcoma Risk and Prognosis
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October 2, 2025

Insights from the AACR Special Conference in Cancer Research: Discovery and Innovation in Pediatric Cancer
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September 25, 2025

Open-label, cohort-sequential dose-escalation and dose-confirmation Phase 1/2 clinical trial to evaluate the safety and efficacy of domatinostat in combination with sirolimus in adolescents and adults with relapsed, refractory sarcoma and osteosarcoma
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September 11, 2025

Distinct Patterns of Chromosomal Instability Fuel Osteosarcoma Progression and Influence Patient Outcomes
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August 28, 2025

Deciphering the impact of STING agonists on the tumor microenvironment in osteosarcoma
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July 31, 2025

Clinical Biomarkers for Osteosarcoma Stratification (cBOSS): Insights from a Working Group
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July 24, 2025

Simultaneous Targeting of CDK4/6 and BETs is Independent of RB Status in Osteosarcoma
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July 10, 2025

Old Drugs, New Tricks? A Novel Immunomodulatory Approach to Relapsed Osteosarcoma Therapy
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May 29, 2025

Molecular Subtyping of Osteosarcoma, ecDNA and More
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May 8, 2025

A Guide to the FACTOR 2025 Scientific Panels with Matteo Trucco, MD
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April 24, 2025

Autologous Cancer Vaccine with Checkpoint Inhibitor for Treatment of Canine Osteosarcoma
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April 10, 2025

La Cirugía de Salvamento de Extremidades
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April 3, 2025

Advocating for Cures: How You Can Support the Give Kids a Chance Act and Advance Pediatric Cancer Research
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March 27, 2025

Tumor cGAS-STING Repression Drives Immune Evasion in Osteosarcoma and is Therapeutically Targetable via Host STING Activation
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March 13, 2025

Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition
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March 6, 2025

Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis
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February 27, 2025

Multi-Modal Omics Analysis Identifies Targetable Sensory Neuron Circuitry that Promotes Sarcoma Disease Progression
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February 13, 2025

An Organoid-Based Functional Precision Medicine Trial in Osteosarcoma (PREMOST)
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February 6, 2025

Minimally Invasive Metastasectomy in Canines (MIMIC)
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January 23, 2025

Live-Cell Whole Tissue Models Reveal Sources of Dynamic Signaling Heterogeneity and Single Cell Drug Response Variation in the Metastatic Niche
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January 9, 2025

COG Blueprint for Research on Bone Tumors
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December 12, 2024

Understanding Tumor Evolution in Osteosarcoma
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December 5, 2024

Macrophage Engineered Vesicles to Treat Pediatric Osteosarcoma
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November 7, 2024

Repurposing Virus Specific T cells as Immune Therapy for Osteosarcoma
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October 31, 2024

Repurposing Drugs for Osteosarcoma
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October 24, 2024

The Ablative and Immunomodulatory Effects of Histotripsy Treatment in Osteosarcoma
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September 26, 2024

Molecular and Cellular Deconstruction of Metastatic Osteosarcoma
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August 29, 2024

Fit for Filing Academic Clinical Trials: An Industry Perspective
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August 22, 2024

Magnetic Resonance Guided (MRg) High Intensity Focused Ultrasound (HIFU) For Palliation of Canine Appendicular Osteosarcoma
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August 8, 2024

Clinical Utility of Functional Precision Medicine to Guide Treatments for Osteosarcoma Patients
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August 1, 2024

Immune Determinants of CAR-T Cell Expansion in Solid Tumor Patients Receiving GD2 CAR-T Cell Therapy
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July 25, 2024

A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination with Gemcitabine and Docetaxel in Patients with Relapsed or Refractory Pediatric Bone and Soft Tissue (TINKS)
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July 11, 2024

Genomes, Avatars and AI: The Future of Personalized Medicine
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May 30, 2024

Exploring Novel Immunotherapies for Canine Osteosarcoma
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May 23, 2024

A Guide to the FACTOR 2024 Scientific Panels with Matteo Trucco, MD
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May 9, 2024

Creating a Translational Genomic Framework for Canine Osteosarcoma: Updates on the NCI DOG2 Project
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May 2, 2024

Positioning Poly-(ADP)-Ribose Polymerase Inhibitors (PARPi) for the Treatment of Osteosarcoma
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April 25, 2024

TGF-Beta Inhibition as a Novel Therapeutic Option in Osteosarcoma
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April 11, 2024

Phase 1 Study of Cabozantinib in Combination with Topotecan-Cyclophosphamide for Patients with Relapsed or Refractory Ewing Sarcoma or Osteosarcoma
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April 4, 2024

Targeting Urea Cycle Dysfunction to Prevent and Treat Osteosarcoma Metastasis
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March 14, 2024

Osteosarcoma Explorer: A Data Commons With Clinical, Genomic, Protein, and Tissue Imaging Data for Osteosarcoma Research
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March 7, 2024

Patient Perspectives on Participating in Research and Clinical Trials
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February 29, 2024

Tissue Engineering Strategies for Elucidating OS Biology and Drug Discovery
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February 22, 2024

Liquid Biopsy in Ewing Sarcoma and Osteosarcoma as a Prognostic and Response Diagnostic: The LEOPARD Study
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February 8, 2024

Prevention of Cisplatin-Induced Hearing Loss: Implications for Young People Treated for Osteosarcoma
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January 25, 2024

TACOS: A Phase 2 Trial of Atezolizumab and Cabozantinib in Osteosarcoma
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January 11, 2024

Interventions to Promote Physical Function During and After Treatment for Osteosarcoma
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December 14, 2023

The Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan (CAUSAL) study
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December 7, 2023

Developing a Multiscale Transcriptional Atlas of Sarcoma
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November 30, 2023

Immunological Mechanisms of Cancer Defense
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November 2, 2023

An Overview of the 2023-2024 OutSmarting Osteosarcoma Research Grant Program
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October 26, 2023

Cabozantinib as a Maintenance Therapy to Prevent Recurrence of High-Risk Pediatric Solid Tumors
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October 12, 2023

Preguntas y Respuestas con Nino Rainusso, MD
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October 5, 2023

TCF-001 TRACK (Target Rare Cancer Knowledge): A Clinical Trial Studying Precision Medicine in Rare Cancers
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September 28, 2023

Repurposing Disulfiram to Overcome Chemotherapy Resistance in Relapsed Sarcomas
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September 14, 2023

Addressing the Unmet Scientific Challenges in Osteosarcoma Treatment through Innovative Engineering Techniques
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August 31, 2023

Implementing Multi-Targeted Tyrosine Kinase Inhibitors in Combination with Chemotherapy for Osteosarcoma
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August 24, 2023

Immune Therapies in EGFR-Expressing Cancers
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August 10, 2023

Treatment of Osteosarcoma Using Smart Targeted Drug Delivery Nanoplatforms
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August 3, 2023

MIB Agents and SARC: A Case Study in Collaboration
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July 27, 2023

OSI Funded Work
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July 13, 2023

Pretargeted Approach to Delivery of Radiopharmaceutical Therapy for Bone Cancer - A Click Chemistry Study in Canines with Osteosarcoma
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June 8, 2023

The Importance of Osteosarcoma Research: Count Me In's Patient Powered Osteosarcoma Project (OSProject.org)
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June 1, 2023

Osteosarcoma Organoid Models: the Potential and Limitations of Personalized Avatars
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May 25, 2023

Reprogramming NK Cells Within the Tumor Microenvironment of Osteosarcoma Lung Metastases
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May 11, 2023

OSI Connect: Osteosarcoma Answers and Assistance
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May 4, 2023

Phase 1 Trial with GD2-SADA:177Lu-DOTA Drug Complex in Patients with Recurrent or Refractory Metastatic Solid Tumors Known to Express GD2
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April 27, 2023

SCF-Skp2 Protein Complex as a Therapy for Osteosarcoma by Blocking the Mutational Effects of Rb and p53
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April 13, 2023

Cold Atmospheric Plasma: A New Therapeutical Option for Osteosarcoma?
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March 30, 2023

UHRF1 Overexpression Promotes Osteosarcoma Metastasis Through Altered Exosome Production and AMPK/SEMA3E Suppression
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March 23, 2023

SBRT and SRS for Sarcoma
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March 9, 2023

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks
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March 2, 2023

SarcoSIGHT – A Randomised Controlled Trial of Fluorescence Guided Sarcoma Surgery Versus Standard of Care
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February 16, 2023

Virtual Surgical Planning and 3D Printing in Pediatric Musculoskeletal Oncological Resections
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January 26, 2023

Two epigenetically distinct cellular states in osteosarcoma are regulated by a state-specific set of transcription factors driving differential drug response
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January 12, 2023

Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors
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December 8, 2022

Cell based therapies for osteosarcoma
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November 10, 2022

Interventional Radiology/HIFU perspectives for osteosarcoma
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November 3, 2022

Focal Adhesion Kinase (FAK) inhibition to improve losartan-sunitinib immunotherapy in metastatic osteosarcoma
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October 27, 2022

Updates from clinical sequencing of 2,138 bone and soft tissue sarcomas
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October 20, 2022

osTEAo: Halloween Spooky Stories
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October 13, 2022

How Osteosarcoma Evolves from Diagnosis to Relapse
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October 6, 2022

Transforming the Way Researchers Share Data: Lessons from the Pediatric Cancer Data Commons
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September 22, 2022

OsTEAo: Dating & Intimacy with Lauren Broschak, MSW, LCSW, OSW-C
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September 15, 2022

Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma
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September 8, 2022

A report on the phase I/II study of single-agent lenvatinib in children and adolescents with refractory or relapsed solid malignancies and young adults with osteosarcoma
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September 1, 2022

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response
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August 25, 2022

Outsmarting OS 2021 Funded Research Update: Exploring Aldehyde Dehydrogenase and Androgen Receptor Actions to OutSmart Osteosarcoma Metastases
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August 18, 2022

OsTEAo: Back To School
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August 11, 2022

Combination Therapies to Improve Immune-Mediated Approaches for Osteosarcoma
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August 4, 2022

Using RNA-nanoparticle vaccines to overcome the immunosuppressive tumor microenvironment of canine osteosarcoma
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July 28, 2022

COG Project: Every Child
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