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Clinical Trial Highlights

This curate list of clinical trials includes studies that are interventional, specific to osteosarcoma, and currently recruiting..
Studies are listed in order of study start date.

Learn About Clinical Trials

 Explore Clinical Trial Webinars on OsteoBites

Clinical Trial Glossary

Clinical Trial Status

Withdrawn

Before enrolling its first patient, the study was stopped.

Completed

These clinical trials have finished normally and treatment and/or follow-up visits have ended.

Terminated

These clinical trials have ended early and will not start again. When a clinical trial is terminated, it means participants stop being treated or followed. 

Suspended

These clinical trials have been stopped early but they may start again.

Active, not recruiting

These clinical trials are already underway and new participants are not being enrolled.

Enrolling by Invitation

These studies are not open to the general public even if a person meets all eligibility criteria. Instead, a select group of patients determined by the researchers are invited to join the trial.

Recruiting

Patients who meet eligibility criteria are currently being enrolled in these clinical trials

Not yet recruiting

The researchers have not yet started recruiting patients for these clinical trials

Study Design

Cross-over assignment

Groups of participants are treated with multiple interventions in a specific order. For instance, participants in one group will receive drug A first and drug B second, while participants in another group with receive drug B first and drug A second.

No intervention arm

Participants do not receive any intervention or treatment.

Sham comparator arm

Participants receive a device or procedure that is made to look the same as the device or procedure that is being studied in the clinical trial, but does not have any active components

Placebo comparator arm

Participants receive a placebo, a treatment that has no therapeutic effect.

Active comparator arm

Participants receive a type of treatment that is already known to be effective

Experimental arm

Participants receive the treatment that is the subject of the clinical trial.

Arm

A group or subgroup of participants in a clinical trial (usually an interventional study) that receives the same intervention or no intervention, consistent with the study protocol. 

Cohort

A group of participants who share the same characteristics. Cohorts are often used in observational studies. 

Observational study

A type of clinical study design where researchers observe participants but do not control the treatment they receive. These types of studies are usually done when it is difficult or unethical to randomly assign participants to experimental groups.

Interventional study

 A type of clinical study design that allows researchers to test a potential treatment (or intervention) in participants.

Informed Consent

The process used to make participants in clinical trials aware of potential risks and benefits of participation. 

Assent

An adolescent’s agreement to participate in a clinical trial. Before giving assent, the clinical trial must be explained in a way the child can understand. Additionally, both parents need to permit participation.

Inclusion Criteria

Systemic therapy

Cancer treatment that targets the entire body. Chemotherapy is the most common form of Systemic cancer therapy. 

Local control

Cancer that has not grown or spread past the primary site.

Metastatic

Cancer that has spread from where it started (call the primary site) to other parts of the body.

Refractory

Cancer is not responding to treatment.

Recurrent

Cancer has returned after treatment and after a period where no cancer was detected.

Resectable

Cancer or tumor that can be removed completely with surgery

Unresectable

Cancer or tumor that cannot be removed completely with surgery

Outcomes

All-cause mortality

Used to measure deaths from all causes that occurred during a clinical trial.

Serious adverse event

Any unwanted medical occurrence that is considered life-threatening, leads to hospitalization or increases existing hospitalization, disrupts the ability to conduct normal life functions, leads to congenital anomalies or birth defects, or results in death. 

Adverse event

Any unwanted medical occurrence that takes place during a clinical trial or within the follow-up period. These events may or may not be caused by participation in the clinical trial.